Arsenal fell behind early in the first half at Old Trafford last Sunday and was beaten by a young, largely inexperienced Manchester United side.
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Things have been much brighter for Pochettino and Tottenham, despite a 1-0 loss to West Ham on Wednesday. Spurs are well placed to win a first league title since 1961.
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Young midfielder Dele Alli has been one of the revelations of the Premier League season, providing a spark going forward.
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Harry Kane continues to score goals, a season after he made his breakthrough in the Premier League.
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Tottenham also has the stingiest defense in the division, with goalkeeper Hugo Lloris playing his part.
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If Tottenham is to win Saturday, it may need to stop Mesut Ozil, who is closing in on the Premier League assist record.
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Tottenham and Arsenal are vying with the league's biggest surprise package, Leicester City managed by Claudio Ranieri (seen parodied here) for top spot in the division.