Serena Williams shakes hands with Madison Keys after winning the all-American clash on Arthur Ashe.Alex Goodlett/Getty Images North America/Getty Images
Venus Williams of the United States celebrates after defeating Anett Kontaveit of Estonia in their fourth round match.Clive Brunskill/Getty Images North America/Getty Images
Venus and Serena have won 28 grand slam singles titles between them and shared 13 grand slam doubles titles.Paul Gilham/Getty Images Europe/Getty Images
Serena leads the career head to head 15-11 with the most recent victory at Wimbledon in July.Streeter Lecka/Getty Images