
Sofia Vergara has snagged a role as Bart's new teacher Mrs. Berrera in season 27 of "The Simpsons." The "Modern Family" star is just one of many celebs who have graced Springfield in bit parts over the years.

Kelsey Grammer may be the most famous "Simpsons" guest star of all time. His Sideshow Bob has made recurring appearances after beginning as a sidekick on Krusty the Clown's TV show.

It was a natural fit for "The Simpsons" to cast David Hyde Pierce as Sideshow Bob's brother, Cecil Terwiliger. The actor appeared as Grammer's character's brother on the sitcom "Frasier."

Life coach Colby Krause looks a lot like "The Late Show" host Stephen Colbert, who voiced the character.

Famed director John Waters pretty much played a toned-down version of himself as John, a gay family friend.

Danny DeVito appeared as Homer's older half-brother, Herbert Powell. He's smarter and more successful than his younger brother -- at least initially.

Alex Whitney was Lisa's popular classmate who enjoyed the more mature pursuits of dating and shopping with credit cards. Lisa Kudrow voiced the character.

Penny Marshall's Lucille Botzcowski was absolutely terrifying. Known as "Ms. Botz," she was the Simpson children's criminal-minded babysitter.

Jeff Goldblum appeared as MacArthur Parker, the agent of Phil Hartman's cheesy actor Troy McClure.

It was a show inside a show when Neil Patrick Harris appeared as Bart in the made-for-TV movie "Blood on the Blackboard: The Bart Simpson Story."

Sara Gilbert is best known as a child star on "Roseanne" and co-host of "The Talk," but she also set Bart's heart to racing as Laura in one episode.

The legendary Albert Brooks lent his voice to the character of evil entrepreneur Hank Scorpio.

Mr. Bergstrom the substitute teacher made quite the impression on Lisa Simpson. He was voiced by Oscar winner Dustin Hoffman.

Three actresses have portrayed Homer's mother, Mona Simpson, over the years, with Glenn Close the most notable.

Jon Lovitz has voiced a few Simpsons characters over the years, including Marge's old boyfriend Artie Ziff.

Meryl Streep is revered as one of the greatest actresses of all time. and she nailed it as Rev. Lovejoy's manipulative daughter Jessica, who is Bart's crush.

Michelle Pfeiffer's Mindy Simmons almost led Homer astray with her feminine wiles and her love of food.


