Preliminary research now suggests that skin rashes and rashes inside the mouth might be a symptom of coronavirus infection — but more study is needed.
The research, published in the medical journal JAMA Dermatology on Wednesday, found that among 21 patients in Spain who were confirmed to have Covid-19 and a skin rash, six of those patients or 29% had enanthem, or lesions or rash in the mouth.
The mean amount of time between the onset of Covid-19 symptoms and developing enanthem was about 12 days among the patients, according to researchers from the Hospital Universitario Ramon y Cajal in Madrid.
Specifically, the researchers found that one patient developed enanthem 24 days after the onset of symptoms; two patients developed enanthem 19 days after; one developed enanthem 12 days after; one developed enanthem two days after; and another developed enanthem two days before.
"This work describes preliminary observations and is limited by the small number of cases and the absence of a control group," the researchers wrote, adding that their findings still suggest enanthem to be a possible Covid-19 symptom and not a reaction to medications, for instance.
"Despite the increasing reports of skin rashes in patients with COVID-19, establishing an etiological diagnosis is challenging," the researchers wrote. "However, the presence of enanthem is a strong clue that suggests a viral etiology rather than a drug reaction."